Eradication of microflora in the treatment of pulpal and periapical diseases is the crucial step in assuring the successs of endodontic therapy. It is evident that instrumentation alone doesnot render bacteria free root canal system, henceforth irrigants play an very important role in eradicating the microorganisms from the root canal system. This lecture highlighted the importance of irrigants, newer trends in irrigation devices and the irrigants available. It helped the participants to gain knowledge regarding the recent advances in irrigation protocols and imply them in their clinical practice.