Department of Conservative Dentistry and Endodontics conducted a guest lecture on “Probiotics and Caries Prevention” on 20.9.19 at Saveetha Dental College presented by Dr. S. Poorni, Reader, Sri Venkateshwara Dental and Hospital, Thalambur. The occurrence of dental caries due to the vital role of the microbial bioﬁlm is a subject of interest for both researchers and clinicians who are looking for means to establish the methods for prevention and treatment of the disease. Though there are a number of caries prevention strategies that are evolving, fluorides and probiotics have always been an indispensible part of it. Probiotics are at present the subject of ardent and extensive research, especially in caries prevention wherein administration of an adequate number of live microorganisms will provide oral health beneﬁts to the host. The speaker briefly discussed on caries formation and highlighted on preventive strategies including fluorides and probiotics.