Department of Conservative Dentistry and Endodontics organized a guest lecture on “Role of Platelet Rich Fibrin and its Biological Mediators in Dentistry” on 15.3.19 presented by Dr. K. Anil Kumar, Reader, Department of Periodontology, Meenakshi Ammal Dental College, Chennai. Research into regenerative dentistry has added impetus onto the field of molecular biology. It can be documented as a prototype shift in the therapeutic armamentarium for dental disease. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. A new family of platelet concentrates called the platelet rich fibrin (PRF) has been recently used by several investigators and has shown application in diverse disciplines of dentistry. This lecture deliberated on the various prospects of PRF, and its clinical and molecular insights to dentistry.